Francesco Fedele Selected Research

Simendan (Levosimendan)

2/2021	Levosimendan in Europe and China: An Appraisal of Evidence and Context.
3/2020	Levosimendan Efficacy and Safety: 20 years of SIMDAX in Clinical Use.
1/2020	Levosimendan Efficacy and Safety: 20 Years of SIMDAX in Clinical Use.
12/2019	A pragmatic approach to the use of inotropes for the management of acute and advanced heart failure: An expert panel consensus.
11/2019	Short-Term Therapies for Treatment of Acute and Advanced Heart Failure-Why so Few Drugs Available in Clinical Use, Why Even Fewer in the Pipeline?
1/2019	Repetitive levosimendan infusions for patients with advanced chronic heart failure in the vulnerable post-discharge period.
12/2018	Repetitive levosimendan treatment in the management of advanced heart failure.
9/2017	Repetitive use of levosimendan in advanced heart failure: need for stronger evidence in a field in dire need of a useful therapy.
3/2017	Pharmacological approaches to cardio-renal syndrome: a role for the inodilator levosimendan.
11/2016	Levosimendan beyond inotropy and acute heart failure: Evidence of pleiotropic effects on the heart and other organs: An expert panel position paper.

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Francesco Fedele Research Topics

Disease

28	Heart Failure 10/2021 - 05/2003
14	Myocardial Infarction 01/2021 - 08/2004
10	ST Elevation Myocardial Infarction 01/2021 - 11/2006
10	Thrombosis (Thrombus) 01/2018 - 01/2006
9	Coronary Artery Disease (Coronary Atherosclerosis) 10/2020 - 01/2005
9	Pulmonary Hypertension 03/2020 - 09/2005
8	Pulmonary Arterial Hypertension 12/2021 - 01/2006
7	Neoplasms (Cancer) 02/2021 - 01/2002
6	COVID-19 01/2022 - 08/2020
6	Necrosis 03/2021 - 01/2012
6	Hypertension (High Blood Pressure) 11/2020 - 11/2003
6	Myocardial Ischemia (Ischemic Heart Diseases) 04/2020 - 01/2009
5	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 06/2005
5	Heart Diseases (Heart Disease) 04/2021 - 05/2012
5	Atrial Fibrillation 02/2021 - 01/2011
5	Takotsubo Cardiomyopathy 03/2020 - 12/2013
5	Left Ventricular Dysfunction 01/2019 - 05/2003
5	Acute Coronary Syndrome 08/2007 - 07/2004
4	Infections 09/2022 - 12/2010
4	Cardiomyopathies (Cardiomyopathy) 01/2022 - 02/2019
4	Aortic Valve Stenosis (Aortic Stenosis) 05/2021 - 06/2004
4	Ventricular Tachycardia 04/2021 - 05/2003
4	Inflammation (Inflammations) 01/2021 - 02/2008
4	Coronary Disease (Coronary Heart Disease) 11/2020 - 07/2004
4	Familial Primary Pulmonary Hypertension 01/2020 - 09/2005
4	Death (Near-Death Experience) 01/2018 - 09/2010
4	Stable Angina 10/2013 - 01/2006
4	Infarction (Infarctions) 09/2010 - 12/2004
3	Cardiac Arrhythmias (Arrythmia) 01/2022 - 01/2011
3	Ischemia 07/2020 - 07/2004
3	Stroke (Strokes) 02/2019 - 01/2013
3	Hypotension (Low Blood Pressure) 03/2017 - 05/2003
3	Pathologic Constriction (Stenosis) 11/2011 - 01/2005
3	Cardiac Sudden Death (Sudden Cardiac Arrest) 01/2009 - 10/2007
2	Hemorrhage 01/2022 - 02/2019
2	Ventricular Premature Complexes (Premature Ventricular Contraction) 04/2021 - 03/2020
2	Cicatrix (Scar) 04/2021 - 03/2020
2	Shock 01/2021 - 11/2010
2	HIV Infections (HIV Infection) 07/2020 - 09/2014
2	Fibrosis (Cirrhosis) 04/2020 - 03/2014
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 03/2020 - 01/2020
2	Cardiogenic Shock 03/2020 - 01/2020
2	Heart Arrest (Cardiac Arrest) 01/2019 - 02/2003
2	Diabetes Mellitus 03/2018 - 01/2008
2	Sudden Death 07/2017 - 05/2003
2	Edema (Dropsy) 03/2014 - 11/2012
2	Coronary Stenosis (Coronary Artery Stenosis) 01/2012 - 07/2004
2	Ventricular Remodeling 02/2008 - 11/2006
2	Coronary Restenosis 01/2008 - 07/2007
2	Hyponatremia 12/2007 - 12/2005

Drug/Important Bio-Agent (IBA)

18	Simendan (Levosimendan)IBA 02/2021 - 06/2004
7	Ion Channels (Ion Channel)IBA 04/2021 - 11/2013
6	CalciumIBA 02/2021 - 06/2004
6	Paclitaxel (Taxol)FDA LinkGeneric 01/2008 - 01/2005
5	DiureticsIBA 01/2022 - 08/2010
5	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 11/2020 - 05/2003
5	Pharmaceutical PreparationsIBA 01/2020 - 01/2004
4	Biomarkers (Surrogate Marker)IBA 06/2022 - 01/2012
4	CatecholaminesIBA 03/2021 - 11/2008
4	Dobutamine FDA LinkGeneric 12/2019 - 06/2004
4	Brain Natriuretic Peptide (Natrecor)FDA Link 11/2019 - 11/2008
3	TroponinIBA 06/2022 - 12/2004
3	Oxygen (Dioxygen)IBA 01/2021 - 09/2005
3	Angiotensin Receptor AntagonistsIBA 11/2020 - 01/2009
3	omega-Chloroacetophenone (Mace)IBA 01/2018 - 06/2005
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2013 - 01/2011
3	Phenobarbital (Luminal)FDA Link 01/2012 - 01/2008
3	Abciximab (ReoPro)FDA Link 07/2010 - 06/2005
3	Sirolimus (Rapamycin)FDA Link 02/2006 - 01/2005
2	AnticoagulantsIBA 02/2021 - 10/2019
2	CholesterolIBA 11/2020 - 09/2010
2	Vasodilator Agents (Vasodilators)IBA 12/2019 - 07/2015
2	GadoliniumIBA 05/2019 - 03/2014
2	IvabradineIBA 01/2019 - 09/2010
2	3-Iodobenzylguanidine (Iobenguane)IBA 01/2017 - 11/2016
2	Rosuvastatin Calcium (Crestor)FDA Link 10/2013 - 01/2013
2	Endothelin-1 (Endothelin 1)IBA 07/2013 - 10/2012
2	Bosentan (Tracleer)FDA Link 07/2013 - 11/2008
2	IronIBA 05/2013 - 10/2007
2	ChromatinIBA 04/2013 - 07/2008
2	Biological ProductsIBA 05/2012 - 01/2002
2	ProstaglandinsIBA 04/2012 - 01/2006
2	ElectrolytesIBA 08/2010 - 01/2009
2	Keratins (Keratin)IBA 07/2008 - 01/2008
2	Antidiuretic Hormone Receptor AntagonistsIBA 12/2007 - 12/2005
2	SodiumIBA 12/2007 - 06/2004

Therapy/Procedure

36	Therapeutics 01/2022 - 01/2002
17	Percutaneous Coronary Intervention 05/2019 - 01/2005
10	Stents 01/2018 - 01/2005
5	Catheters 01/2022 - 01/2009
5	Drug-Eluting Stents 01/2008 - 01/2005
4	Thrombectomy 09/2010 - 01/2008
3	Transcatheter Aortic Valve Replacement 01/2022 - 01/2021
3	Drug Therapy (Chemotherapy) 11/2020 - 10/2008
3	Patient Readmission 01/2016 - 03/2013
2	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 01/2021 - 05/2003
2	Artificial Respiration (Mechanical Ventilation) 09/2020 - 11/2010
2	Critical Care (Surgical Intensive Care) 03/2020 - 01/2020
2	Defibrillators (Defibrillator) 02/2019 - 02/2003
2	Highly Active Antiretroviral Therapy (HAART) 07/2017 - 09/2014